Modeling and simulation of the main metabolism in Escherichia coli and its several single-gene knockout mutants with experimental verification

@inproceedings{Kadir2010ModelingAS,
  title={Modeling and simulation of the main metabolism in Escherichia coli and its several single-gene knockout mutants with experimental verification},
  author={Tuty Asmawaty Abdul Kadir and Ahmad A. Mannan and Andrzej M. Kierzek and Johnjoe McFadden and Kazuyuki Shimizu},
  booktitle={Microbial cell factories},
  year={2010}
}
BACKGROUND It is quite important to simulate the metabolic changes of a cell in response to the change in culture environment and/or specific gene knockouts particularly for the purpose of application in industry. If this could be done, the cell design can be made without conducting exhaustive experiments, and one can screen out the promising candidates, proceeded by experimental verification of a select few of particular interest. Although several models have so far been proposed, most of them… CONTINUE READING
25 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Effect of a pyruvate kinase (pykF-gene) knockout mutation on the control of gene expression and metabolic fluxes in Escherichia coli

  • KAZ Siddique, MJ Arauzo-Bravo, K Shimizu
  • FEMS Microbiology Letters
  • 2004
Highly Influential
5 Excerpts

Toward systematic metabolic engineering based on the analysis of metabolic regulation by the integration of different levels of information

  • K Shimizu
  • Biochem Eng
  • 2010
2 Excerpts

Similar Papers

Loading similar papers…