Modeling and simulation of intracellular dynamics: choosing an appropriate framework

  title={Modeling and simulation of intracellular dynamics: choosing an appropriate framework},
  author={Olaf Wolkenhauer and Mukhtar Ullah and Walter Kolch and Kwang-Hyun Cho},
  journal={IEEE Transactions on NanoBioscience},
Systems biology is a reemerging paradigm which, among other things, focuses on mathematical modeling and simulation of biochemical reaction networks in intracellular processes. For most simulation tools and publications, they are usually characterized by either preferring stochastic simulation or rate equation models. The use of stochastic simulation is occasionally accompanied with arguments against rate equations. Motivated by these arguments, we discuss in this paper the relationship between… 

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