Modeling and protein engineering studies of active and inactive states of human dopamine D2 receptor (D2R) and investigation of drug/receptor interactions

@article{Salmas2015ModelingAP,
  title={Modeling and protein engineering studies of active and inactive states of human dopamine D2 receptor (D2R) and investigation of drug/receptor interactions},
  author={R. E. Salmas and M. Yurtsever and M. Stein and S. Durdagi},
  journal={Molecular Diversity},
  year={2015},
  volume={19},
  pages={321-332}
}
  • R. E. Salmas, M. Yurtsever, +1 author S. Durdagi
  • Published 2015
  • Biology, Medicine
  • Molecular Diversity
  • Homology model structures of the dopamine D2 receptor (D2R) were generated starting from the active and inactive states of $$\upbeta $$β2-adrenergic crystal structure templates. To the best of our knowledge, the active conformation of D2R was modeled for the first time in this study. The homology models are built and refined using MODELLER and ROSETTA programs. Top-ranked models have been validated with ligand docking simulations and in silico Alanine-scanning mutagenesis studies. The derived… CONTINUE READING
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