Modeling and Validating Chronic Pharmacological Manipulation of Circadian Rhythms

@inproceedings{Kim2013ModelingAV,
  title={Modeling and Validating Chronic Pharmacological Manipulation of Circadian Rhythms},
  author={Jeungkun Kim and Daniel B. Forger and Miriam Marconi and David Wood and Andra Doran and Tor Wager and Chien Chang and Kevin M. Walton},
  booktitle={CPT: pharmacometrics & systems pharmacology},
  year={2013}
}
Circadian rhythms can be entrained by a light-dark (LD) cycle and can also be reset pharmacologically, for example, by the CK1δ/ε inhibitor PF-670462. Here, we determine how these two independent signals affect circadian timekeeping from the molecular to the behavioral level. By developing a systems pharmacology model, we predict and experimentally validate… CONTINUE READING