Modeling and Robustness Analysis of Biochemical Networks of Glycerol Metabolism by Klebsiella Pneumoniae

@inproceedings{Ye2009ModelingAR,
  title={Modeling and Robustness Analysis of Biochemical Networks of Glycerol Metabolism by Klebsiella Pneumoniae},
  author={Jianxiong Ye and Enmin Feng and Lei Wang and Zhilong Xiu and Yaqin Sun},
  booktitle={Complex},
  year={2009}
}
Glycerol bioconversion to 1,3-propanediol (1,3-PD) by Klebsiella pneumoniae (K. pneumoniae) can be characterized by an intricate network of interactions among biochemical fluxes, metabolic compounds, key enzymes and genetic regulatory. To date, there still exist some uncertain factors in this complex network because of the limitation in bio-techniques, especially in measuring techniques for intracellular substances. In this paper, among these uncertain factors, we aim to infer the transport… 
Complex metabolic network of 1,3-propanediol transport mechanisms and its system identification via biological robustness
TLDR
A 14-dimensional nonlinear hybrid dynamical system aiming to determine the most possible metabolic system and the corresponding optimal parameter is established and numerical results show that it is most possible that 1,3-PD passes the cell membrane by active transport coupled with passive diffusion.
Determining the transport mechanism of an enzyme-catalytic complex metabolic network based on biological robustness
  • Lei Wang
  • Computer Science
    Bioprocess and Biosystems Engineering
  • 2012
TLDR
A system identification model is presented to infer the most possible transport mechanism of 1,3-PD, in which the performance index consists of the relative error of the extracellular substance concentrations and biological robustness of the intracellular substances concentrations.
Parameter identification of nonlinear delayed dynamical system in microbial fermentation based on biological robustness
TLDR
The nonlinear enzyme-catalytic kinetic system of batch and continuous fermentation in the process of glycerol bio-dissimilation is investigated and the delay of concentration changes on both extracellular substances and intracellular substances is considered.
Modeling and identification of hybrid dynamic system in microbial continuous fermentation
TLDR
A hybrid dynamic model using fuzzy expert system is investigated in the process of glycerol bioconversion to 1,3-PD by Klebsiella pneumoniae and indicates that proposed hybrid model adding fuzzy system is more appropriate and the optimization algorithm is effective.
MICROBIAL CONTINUOUS FERMENTATION
In this paper, a hybrid dynamic model using fuzzy expert system is investigated in the process of glycerol bioconversion to 1,3-PD by Klebsiella pneumoniae(K.pneumoniae). In continuous culture, we

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