Modeling an autism risk factor in mice leads to permanent immune dysregulation.

  title={Modeling an autism risk factor in mice leads to permanent immune dysregulation.},
  author={Elaine Y. Hsiao and Sara W. McBride and Janet Chow and S K Mazmanian and Paul H. Patterson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 31},
Increasing evidence highlights a role for the immune system in the pathogenesis of autism spectrum disorder (ASD), as immune dysregulation is observed in the brain, periphery, and gastrointestinal tract of ASD individuals. Furthermore, maternal infection (maternal immune activation, MIA) is a risk factor for ASD. Modeling this risk factor in mice yields offspring with the cardinal behavioral and neuropathological symptoms of human ASD. In this study, we find that offspring of immune-activated… CONTINUE READING
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