Modeling amantadine treatment of influenza A virus in vitro.

@article{Beauchemin2008ModelingAT,
  title={Modeling amantadine treatment of influenza A virus in vitro.},
  author={Catherine A A Beauchemin and James J. McSharry and George L. Drusano and Jack T. Nguyen and Gregory T. Went and Ruy M. Ribeiro and Alan S. Perelson},
  journal={Journal of theoretical biology},
  year={2008},
  volume={254 2},
  pages={
          439-51
        }
}
We analyzed the dynamics of an influenza A/Albany/1/98 (H3N2) viral infection, using a set of mathematical models highlighting the differences between in vivo and in vitro infection. For example, we found that including virion loss due to cell entry was critical for the in vitro model but not for the in vivo model. Experiments were performed on influenza virus-infected MDCK cells in vitro inside a hollow-fiber (HF) system, which was used to continuously deliver the drug amantadine. The HF… CONTINUE READING

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