Modeling a model: Mouse genetics, 22q11.2 Deletion Syndrome, and disorders of cortical circuit development.

@article{Meechan2015ModelingAM,
  title={Modeling a model: Mouse genetics, 22q11.2 Deletion Syndrome, and disorders of cortical circuit development.},
  author={Daniel W. Meechan and Thomas M Maynard and Eric S. Tucker and Alejandra Fern{\'a}ndez and Beverly A. Karpinski and Lawrence A Rothblat and Anthony-S. LaMantia},
  journal={Progress in neurobiology},
  year={2015},
  volume={130},
  pages={1-28}
}
Understanding the developmental etiology of autistic spectrum disorders, attention deficit/hyperactivity disorder and schizophrenia remains a major challenge for establishing new diagnostic and therapeutic approaches to these common, difficult-to-treat diseases that compromise neural circuits in the cerebral cortex. One aspect of this challenge is the breadth and overlap of ASD, ADHD, and SCZ deficits; another is the complexity of mutations associated with each, and a third is the difficulty of… CONTINUE READING
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