Modeling a field trial of the RTS,S/AS02A malaria vaccine.

  title={Modeling a field trial of the RTS,S/AS02A malaria vaccine.},
  author={Nicolas Maire and John J. Aponte and Amanda Ross and Ricardo Thompson and Pedro Alonso and J{\"u}rg Utzinger and Marcel Tanner and Thomas A. Smith},
  journal={The American journal of tropical medicine and hygiene},
  volume={75 2 Suppl},
A double-blind, phase IIb, randomized controlled trial of the malaria vaccine RTS,S/AS02A showed an efficacy of 45.0% in reducing the force of infection for Plasmodium falciparum and of 29.9% in reducing incidence of clinical malaria in children 1-4 years of age in Manhiça, Mozambique. We simulate this trial using a stochastic model of P. falciparum epidemiology, and the setting-specific seasonal pattern of entomologic inoculations as input. The simulated incidence curve for the control group… CONTINUE READING