Modeling Tracer Transport in an Osteon under Cyclic Loading

@article{Wang2000ModelingTT,
  title={Modeling Tracer Transport in an Osteon under Cyclic Loading},
  author={Liyun Wang and Stephen Cowin and Sheldon Weinbaum and Susannah Fritton},
  journal={Annals of Biomedical Engineering},
  year={2000},
  volume={28},
  pages={1200-1209}
}
A mathematical model is developed to explain the fundamental conundrum as to how during cyclic mechanical loading there can be net solute (e.g., nutrient, tracer) transport in bone via the lacunar-canalicular porosity when there is no net fluid movement in the canaliculi over a loading cycle. Our hypothesis is that the fluid space in an osteocytic lacuna facilitates a nearly instantaneous mixing process of bone fluid that creates a difference in tracer concentration between the inward and… CONTINUE READING

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