Modeling Sleep Data for a New Drug in Development using Markov Mixed-Effects Models

@article{Kjellsson2011ModelingSD,
  title={Modeling Sleep Data for a New Drug in Development using Markov Mixed-Effects Models},
  author={Maria C. Kjellsson and Dani{\`e}le Ouellet and Brian W. Corrigan and Mats O. Karlsson},
  journal={Pharmaceutical Research},
  year={2011},
  volume={28},
  pages={2610-2627}
}
ABSTRACTPurposeTo characterize the time-course of sleep in insomnia patients as well as placebo and concentration-effect relationships of two hypnotic compounds, PD 0200390 and zolpidem, using an accelerated model-building strategy based on mixed-effects Markov models.MethodsData were obtained in a phase II study with the drugs. Sleep stages were recorded during eight hours of sleep for two nights per treatment for the five treatments. First-order Markov models were developed for one transition… Expand
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