Modeling Sjögren's syndrome with Id3 conditional knockout mice.

Abstract

The Id3 gene has been shown to play important roles in the development and function of broad tissue types including B and T cells. Id3 deficient mice develop autoimmune disease similar to human Sjögren's syndrome. Both B and T lymphocytes have been implicated to contribute to the disease phenotype in this disease model. In order to gain a better… (More)
DOI: 10.1016/j.imlet.2010.09.009

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