• Corpus ID: 37646642

Modeling Quorum Sensing in Sinorhizobium Meliloti

  title={Modeling Quorum Sensing in Sinorhizobium Meliloti},
  author={Matthew McIntosh and Peter Czuppon and Katharine Best and Anke Becker and Peter Pfaffelhuber},
For bacteria, it is important for survival to sense their population density or quorum. We present a minimal mathematical model for quorum sensing in the nitrogen-fixing bacterium Sinorhizobium meliloti based on a system of differential equations, which was set up using data from microbiological experiments. The quorum sensing system depends upon the players ExpR, SinR, SinI and AHL, the signaling molecule within the system. The quorum sensing system undergoes three stages. At low cell density… 

Figures from this paper

Riboregulation in plant-associated α-proteobacteria
Genome-wide analyses of hfq mutants and co-immunoprecipitation with tagged Hfq revealed a major impact of the RNA chaperone on the physiology of plant-associated α-proteobacteria including symbiosis and virulence, as well as RNA degradation is an important process in RNA-based gene regulation.
RNase E Affects the Expression of the Acyl-Homoserine Lactone Synthase Gene sinI in Sinorhizobium meliloti
This study demonstrates that ectopic expression of the gene rne, coding for RNase E, an endoribonuclease that is probably essential for growth, prevents the accumulation of AHLs at detectable levels, and postulates thatRNase E-dependent degradation of sinI mRNA from the 5' end is one of the steps mediating a high turnover of Sin quorum-sensing system to respond rapidly to changes in transcriptional control of AHL production.


Role of Quorum Sensing in Sinorhizobium meliloti-Alfalfa Symbiosis
It is discovered that the ExpR/Sin quorum-sensing system is repressed after plant invasion, and plays a crucial role in the regulation of many cell functions that ensures the successful invasion of the host and is inactivated once symbiosis is established.
Quorum Sensing Controls Exopolysaccharide Production in Sinorhizobium meliloti
The sinRI locus exerts one level of control through regulation of EPS II synthesis and the absence of symbiotically active EPS II in a sinI mutant was confirmed in plant nodulation assays, emphasizing the role of quorum sensing in symbiosis.
Mathematical modelling of quorum sensing in bacteria.
A mathematical model which describes bacterial population growth and quorum sensing in a well mixed system is proposed and studied and it is believed that in general one physical steady-state solution exists and is linearly stable; this solution is believed to be a global attractor.
Regulation of Motility by the ExpR/Sin Quorum-Sensing System in Sinorhizobium meliloti
It is demonstrated that the ExpR/Sin quorum-sensing system controls motility gene expression through the VisN/VisR/Rem relay, and it is shown that the ExoS-dependent two-component system suppresses motility genes expression through VisN and Rem in parallel to quorum sensing.
Novel Sinorhizobium meliloti quorum sensing positive and negative regulatory feedback mechanisms respond to phosphate availability
The Sin quorum sensing system of Sinorhizobium meliloti depends upon at least three genes, sinR, sinI and expR, and N‐acyl homoserine lactones (AHLs) as signals to regulate multiple processes in its
Sinorhizobium meliloti regulator MucR couples exopolysaccharide synthesis and motility.
The ExpR-mediated regulation of motility was attributed to the ability of ExpR to bind a DNA sequence upstream of visN when activated by N-acyl-homoserine lactone and MucR, previously characterized as a regulator of EPS production, also affected motility.
The LuxR homolog ExpR, in combination with the Sin quorum sensing system, plays a central role in Sinorhizobium meliloti gene expression.
A model for the regulation of gene expression by the Sin/ExpR quorum sensing system and another possible quorum Sensing system(s) in S. meliloti is proposed.
A spatial model of the evolution of quorum sensing regulating bacteriocin production
This paper explores the evolutionary stability of QS as a regulatory mechanism of antibiotics production in a spatially structured population, using cellular automaton (CA) modeling and predicts that stable QS may evolve provided its costs are small and the critical quorum threshold is neither too low nor too high.
Look who's talking: communication and quorum sensing in the bacterial world
Quorum sensing enables a bacterial population to mount a co-operative response that improves access to nutrients or specific environmental niches, promotes collective defence against other competitor prokaryotes or eukaryotic defence mechanisms and facilitates survival through differentiation into morphological forms better able to combat environmental threats.
LuxR-family 'solos': bachelor sensors/regulators of signalling molecules.
Recent findings on the role played by the unpaired LuxR-family proteins highlight the need to address bacterial behaviour and response to signals in mixed communities and are proposed to call LuxR 'solos' since they act on their own without the need for a cognate signal generator.