Modeling Melanoma In Vitro and In Vivo

  title={Modeling Melanoma In Vitro and In Vivo},
  author={Kimberley A. Beaumont and Nethia Mohana-Kumaran and Nikolas K. Haass},
The behavior of melanoma cells has traditionally been studied in vitro in two-dimensional cell culture with cells adhering to plastic dishes. However, in order to mimic the three-dimensional architecture of a melanoma, as well as its interactions with the tumor microenvironment, there has been the need for more physiologically relevant models. This has been achieved by designing 3D in vitro models of melanoma, such as melanoma spheroids embedded in extracellular matrix or organotypic skin… CONTINUE READING
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