Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology

@inproceedings{Kim2019ModelingHI,
  title={Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology},
  author={Jihoon Kim and Bon-Kyoung Koo and Ki-jun Yoon},
  booktitle={Viruses},
  year={2019}
}
Pathologies induced by viral infections have undergone extensive study, with traditional model systems such as two-dimensional (2D) cell cultures and in vivo mouse models contributing greatly to our understanding of host-virus interactions. However, the technical limitations inherent in these systems have constrained efforts to more fully understand such interactions, leading to a search for alternative in vitro systems that accurately recreate in vivo physiology in order to advance the study… CONTINUE READING
3
Twitter Mentions

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 107 REFERENCES

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2014
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL