Modeling HIV-1 Drug Resistance as Episodic Directional Selection

  title={Modeling HIV-1 Drug Resistance as Episodic Directional Selection},
  author={Ben Murrell and Tulio de Oliveira and Christopher John Seebregts and Sergei L. Kosakovsky Pond and Konrad Scheffler},
  booktitle={PLoS Computational Biology},
The evolution of substitutions conferring drug resistance to HIV-1 is both episodic, occurring when patients are on antiretroviral therapy, and strongly directional, with site-specific resistant residues increasing in frequency over time. While methods exist to detect episodic diversifying selection and continuous directional selection, no evolutionary model combining these two properties has been proposed. We present two models of episodic directional selection (MEDS and EDEPS) which allow the… CONTINUE READING
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