Modeling Gene Regulation in Graded Hypoxia Using Continuous-Time Markov Chains

@inproceedings{Ciptayani2013ModelingGR,
  title={Modeling Gene Regulation in Graded Hypoxia Using Continuous-Time Markov Chains},
  author={Putu Indah Ciptayani and Reza Pulungan},
  year={2013}
}
Received Jul. 6 th , 2013 Accepted Jul. 21 st , 2013 Hypoxia inducible factor (HIF) is the main protein in hypoxia pathway. The response of HIF to changes of oxygen pressure is regulated by 2 oxygen sensors, prolyl hydroxylase (PHD) and factor inhibiting HIF (FIH). Studies have shown that biochemical reactions at molecular level actually exhibit stochastic and random behaviors. Modeling biochemical reactions using purely deterministic method, therefore, ignore these characteristics. Hence, we… CONTINUE READING
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