Modeling GFR trajectories in diabetic nephropathy.

  title={Modeling GFR trajectories in diabetic nephropathy.},
  author={Kevin V Lemley and Derek B. Boothroyd and Kristina L Blouch and Robert G Nelson and Lois I. Jones and Richard A. Olshen and Bryan D. Myers},
  journal={American journal of physiology. Renal physiology},
  volume={289 4},
In an 8-year longitudinal study of Pima Indians with type 2 diabetes and nephropathy, we used statistical techniques that are novel and depend on minimal assumptions to compare longitudinal measurements of glomerular filtration rate (GFR). Individuals enrolled with new-onset microalbuminuria either progressed to macroalbuminuria (progressors, n = 13) or did not progress (nonprogressors, n = 13) during follow-up. Subjects with new-onset macroalbuminuria at screening were also followed (n = 22… CONTINUE READING