Modeling Evolution Using the Probability of Fixation: History and Implications

@article{McCandlish2014ModelingEU,
  title={Modeling Evolution Using the Probability of Fixation: History and Implications},
  author={David Martin McCandlish and Arlin Stoltzfus},
  journal={The Quarterly Review of Biology},
  year={2014},
  volume={89},
  pages={225 - 252}
}
Many models of evolution calculate the rate of evolution by multiplying the rate at which new mutations originate within a population by a probability of fixation. Here we review the historical origins, contemporary applications, and evolutionary implications of these “origin-fixation” models, which are widely used in evolutionary genetics, molecular evolution, and phylogenetics. Origin-fixation models were first introduced in 1969, in association with an emerging view of “molecular” evolution… Expand
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