Modeling Disordered Regions in Proteins Using Rosetta

Abstract

Protein structure prediction methods such as Rosetta search for the lowest energy conformation of the polypeptide chain. However, the experimentally observed native state is at a minimum of the free energy, rather than the energy. The neglect of the missing configurational entropy contribution to the free energy can be partially justified by the assumption… (More)
DOI: 10.1371/journal.pone.0022060

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