Modeling ChIP Sequencing In Silico with Applications

  title={Modeling ChIP Sequencing In Silico with Applications},
  author={Zhengdong D. Zhang and Joel S. Rozowsky and Michael Snyder and Joseph Tung-Chien Chang and Mark Gerstein},
  journal={PLoS Computational Biology},
  pages={469 - 483}
ChIP sequencing (ChIP-seq) is a new method for genomewide mapping of protein binding sites on DNA. It has generated much excitement in functional genomics. To score data and determine adequate sequencing depth, both the genomic background and the binding sites must be properly modeled. To develop a computational foundation to tackle these issues, we first performed a study to characterize the observed statistical nature of this new type of high-throughput data. By linking sequence tags into… CONTINUE READING


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