Modeling Alzheimer's disease and other proteopathies in vivo: Is seeding the key?

Abstract

 Protein misfolding and aberrant polymerization are salient features of virtually all central neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease, triplet repeat disorders, tauopathies, and prion diseases. In many instances, a single amino acid change can predispose to disease by increasing the production and/or changing the… (More)
DOI: 10.1007/s00726-001-0113-7

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@article{Walker2002ModelingAD, title={Modeling Alzheimer's disease and other proteopathies in vivo: Is seeding the key?}, author={Lary C. Walker and Fei Bian and M. J. Callahan and William J. Lipinski and R. A. Durham and Howard Levine}, journal={Amino Acids}, year={2002}, volume={23}, pages={87-93} }