Modeling ALS and FTLD proteinopathies in yeast: an efficient approach for studying protein aggregation and toxicity.

@article{Kryndushkin2011ModelingAA,
  title={Modeling ALS and FTLD proteinopathies in yeast: an efficient approach for studying protein aggregation and toxicity.},
  author={Dmitry S Kryndushkin and Frank Shewmaker},
  journal={Prion},
  year={2011},
  volume={5 4},
  pages={250-7}
}
In recent years there have been several reports of human neurodegenerative diseases that involve protein misfolding being modeled in the yeast Saccharomyces cerevisiae. This review summarizes recent advances in understanding the specific mechanisms underlying intracellular neuronal pathology during Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD), including SOD1, TDP-43 and FUS protein inclusions and the potential of these proteins to be involved in pathogenic… CONTINUE READING
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