Modeling, docking, and simulation of the major facilitator superfamily.

@article{Holyoake2006ModelingDA,
  title={Modeling, docking, and simulation of the major facilitator superfamily.},
  author={John Holyoake and Victoria Caulfeild and Stephen A. Baldwin and Mark S. P. Sansom},
  journal={Biophysical journal},
  year={2006},
  volume={91 10},
  pages={L84-6}
}
X-ray structures are known for three members of the Major Facilitator Superfamily (MFS) of membrane transporter proteins, thus enabling the use of homology modeling to extrapolate to other MFS members. However, before employing such models for, e.g., mutational or docking studies, it is essential to develop a measure of their quality. To aid development of such metrics, two disparate MFS members (NupG and GLUT1) have been modeled. In addition, control models were created with shuffled sequences… CONTINUE READING

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