Modeled microgravity suppressed expansion of the MBP-specific T lymphocytes of rats with experimental autoimmune encephalomyelitis.


Experimental autoimmune encephalomyelitis (EAE) is characterized by uncontrolled proliferation of autoreactive T lymphocytes, with markedly increased secretion of pro-inflammatory cytokines. To further dissect the pathogenetic pathways of this disease, we exposed T lymphocytes from EAE rats, which were specific for myelin basic protein (MBP) to a modeled… (More)
DOI: 10.3109/08820139.2011.568032