Model to Link Cell Shape and Polarity with Organogenesis

@article{Nielsen2019ModelTL,
  title={Model to Link Cell Shape and Polarity with Organogenesis},
  author={Bjarke Frost Nielsen and Silas Boye Nissen and Kim Sneppen and Ala Trusina and Joachim Mathiesen},
  journal={iScience},
  year={2019},
  volume={23}
}
How do tubes — gut or neural tube — form from flat sheets of polarized cells? The prevalent view is that it is a two-step process: first cells wedge to bend the sheet, then cells intercalate and extend the initial invagination into a tube. We computationally challenged this model by asking if one mechanism (either cell wedging or intercalation) may suffice for the entire sheet-to-tube transition. Using a physical model with epithelial cells represented by polarized point particles, we show that… 
View on PubMed
cell.com
8 Citations
Background Citations
3
Methods Citations
2

8 Citations

A two-tier junctional mechanism drives simultaneous tissue folding and extension.

Polarity Establishment and Maintenance in Ascidian Notochord

The notochord’s mechanical properties are associated with polarity establishment and transformation, which bridge signaling regulation and tissue mechanical properties that enable the coordinated organogenesis during embryo development.

Self-assembly, buckling and density-invariant growth of three-dimensional vascular networks

This model demonstrates convergent extension in the self-assembling process of blood vessels in three dimensions through a set of simple rules that align intercellular apical–basal and planar cell polarity and suggests that the mechanism behind the vascular density-maintaining growth of these islets could be the result of growth-induced buckling.

Mechanisms of vertebrate neural plate internalization.

It is envisioned that more detailed high-resolution quantitative data at both cell and tissue levels will be required to properly model mechanisms of vertebrate neural plate internalization with the hope to prevent human neural tube defects.

Composite morphogenesis during embryo development.

MorphoSim: An efficient and scalable phase-field framework for accurately simulating multicellular morphologies

An improved phase field model is proposed by using the stabilized numerical scheme and modified volume constriction, and a scalable phase-field framework, MorphoSim, is presented, which is 100 times more efficient than the previous one, and can simulate over 100 mechanically interacting cells.

Biophysical models of early mammalian embryogenesis

Curvature strains as a global orchestrator of morphogenesis

Successful morphogenesis on the scale of organs or organisms requires strict coordination between the constituent cells whose action on the local scale must be orchestrated accurately to achieve a…

References

SHOWING 1-10 OF 51 REFERENCES

Three-dimensional epithelial morphogenesis in the developing Drosophila egg.

Radially patterned cell behaviours during tube budding from an epithelium

It is shown that in addition to apical constriction, radially oriented directional intercalation of cells plays a major contribution to early stages of invagination of the salivary gland tube in the Drosophila embryo.

Planar Cell Polarity Links Axes of Spatial Dynamics in Neural-Tube Closure

Apical constriction: a cell shape change that can drive morphogenesis.

Theoretical tool bridging cell polarities with development of robust morphologies

The theoretical tool suggests experimentally testable predictions pointing to the strength of polar adhesion, restricted directions of cell polarities, and the rate of cell proliferation to be major determinants of morphological diversity and stability.

Neurulation: coming to closure

Anisotropy of Crumbs and aPKC Drives Myosin Cable Assembly during Tube Formation

Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration.

An Optogenetic Method to Modulate Cell Contractility during Tissue Morphogenesis

A Vertex Model of Drosophila Ventral Furrow Formation

It is found that the ventral furrow can form through stochastic self-organisation and that previous experimental observations can be readily explained in the model by considering forces that arise when cells execute contractions while being coupled to each other in a mechanically coherent epithelium.
...