Model to Link Cell Shape and Polarity with Organogenesis

@article{Nielsen2019ModelTL,
  title={Model to Link Cell Shape and Polarity with Organogenesis},
  author={Bjarke Frost Nielsen and Silas Boye Nissen and Kim Sneppen and Ala Trusina and Joachim Mathiesen},
  journal={iScience},
  year={2019},
  volume={23}
}
How do tubes — gut or neural tube — form from flat sheets of polarized cells? The prevalent view is that it is a two-step process: first cells wedge to bend the sheet, then cells intercalate and extend the initial invagination into a tube. We computationally challenged this model by asking if one mechanism (either cell wedging or intercalation) may suffice for the entire sheet-to-tube transition. Using a physical model with epithelial cells represented by polarized point particles, we show that… 

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References

SHOWING 1-10 OF 51 REFERENCES

Radially patterned cell behaviours during tube budding from an epithelium

It is shown that in addition to apical constriction, radially oriented directional intercalation of cells plays a major contribution to early stages of invagination of the salivary gland tube in the Drosophila embryo.

Mechanical roles of apical constriction, cell elongation, and cell migration during neural tube formation in Xenopus

A three-dimensional vertex model was employed and apical constriction and cell elongation were inhibited in Xenopus laevis embryos to test whether these three physical events are mechanically sufficient to drive neural tube formation, and suggested that apicalconstriction cued the bending of the neural plate by pursing the circumference of the apical surface of the Neural cells.

Theoretical tool bridging cell polarities with development of robust morphologies

The theoretical tool suggests experimentally testable predictions pointing to the strength of polar adhesion, restricted directions of cell polarities, and the rate of cell proliferation to be major determinants of morphological diversity and stability.

Role of Rab11 in planar cell polarity and apical constriction during vertebrate neural tube closure

It is proposed that anisotropic membrane trafficking plays key roles in diverse morphogenetic behaviors of individual cells and propagates in a tissue by a common mechanism that involves PCP.

Neurulation: coming to closure

Anisotropy of Crumbs and aPKC Drives Myosin Cable Assembly during Tube Formation

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