Model to Link Cell Shape and Polarity with Organogenesis

  title={Model to Link Cell Shape and Polarity with Organogenesis},
  author={Bjarke Frost Nielsen and Silas Boye Nissen and Kim Sneppen and Ala Trusina and Joachim Mathiesen},
How do tubes — gut or neural tube — form from flat sheets of polarized cells? The prevalent view is that it is a two-step process: first cells wedge to bend the sheet, then cells intercalate and extend the initial invagination into a tube. We computationally challenged this model by asking if one mechanism (either cell wedging or intercalation) may suffice for the entire sheet-to-tube transition. Using a physical model with epithelial cells represented by polarized point particles, we show that… 

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