Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

@inproceedings{Mutch2010ModelTF,
  title={Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis},
  author={Nicola J Mutch and Juha Koikkalainen and Steven Fraser and Karolina M. Duthie and Matthew R Griffin and James Mitchell and H Geoffrey Watson and Nuala Booth},
  booktitle={Journal of thrombosis and haemostasis : JTH},
  year={2010}
}
BACKGROUND Activated factor XIII (FXIIIa), a transglutaminase, introduces fibrin-fibrin and fibrin-inhibitor cross-links, resulting in more mechanically stable clots. The impact of cross-linking on resistance to fibrinolysis has proved challenging to evaluate quantitatively. METHODS We used a whole blood model thrombus system to characterize the role of cross-linking in resistance to fibrinolytic degradation. Model thrombi, which mimic arterial thrombi formed in vivo, were prepared with… CONTINUE READING

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References

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Showing 1-10 of 56 references

Functional analysis of fibrin {gamma}-chain cross-linking by activated factor XIII: determination of a cross-linking pattern that maximizes clot stiffness

  • StandevenKF, AM Carter, +5 authors RA. Ariens
  • Blood
  • 2007

a2-antiplasmin must be converted to a derivative form for optimal function

  • MW Mosesson, KR Siebenlist, I Hernandez, KN Lee, VJ Christiansen, PA. McKee
  • J Thromb Haemost
  • 2007

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