Model systems for the discovery and development of antiarrhythmic drugs.

@article{Nattel2008ModelSF,
  title={Model systems for the discovery and development of antiarrhythmic drugs.},
  author={Stanley Nattel and G{\"o}ran Duker and Leif Carlsson},
  journal={Progress in biophysics and molecular biology},
  year={2008},
  volume={98 2-3},
  pages={328-39}
}
Cardiovascular diseases are the leading cause of mortality worldwide and about 25% of cardiovascular deaths are due to disturbances in cardiac rhythm or "arrhythmias". Arrhythmias were traditionally treated with antiarrhythmic drugs, but increasing awareness of the risks of presently available antiarrhythmic agents has greatly limited their usefulness. Most common treatment algorithms still involve small molecule drugs, and antiarrhythmic agents with improved efficacy and safety are sorely… CONTINUE READING
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