Model systems for cardiotoxic effects of anthracyclines.

  title={Model systems for cardiotoxic effects of anthracyclines.},
  author={Gerhard Zbinden and Elisabeth Bachmann and Ch. Holderegger},
  journal={Antibiotics and chemotherapy},
The use of anthracycline antibiotics in cancer chemotherapy is limited by their cardiotoxic qualities. For the evaluation of new derivatives animal model systems are required. Cardiomyopathy can be induced in rabbits and monkeys, but these models are too expensive for screening purposes. In rats, anthracycline antibiotics cause morphologic lesions of the heart muscle, but these are more difficult to demonstrate than in larger animals. However, significant changes of the heart function… CONTINUE READING


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