Model studies towards the total synthesis of the Stemona alkaloid 1-hydroxyprotostemonine: synthesis of ent-1-hydroxystemoamide

@article{Swamy2012ModelST,
  title={Model studies towards the total synthesis of the Stemona alkaloid 1-hydroxyprotostemonine: synthesis of ent-1-hydroxystemoamide},
  author={N. K. Swamy and S. Pyne},
  journal={Heterocycles},
  year={2012},
  volume={84},
  pages={473-492}
}
  • N. K. Swamy, S. Pyne
  • Published 2012
  • Chemistry
  • Heterocycles
  • As part of a model study towards the total synthesis of Stemona alkaloid 1-hydroxyprotostemonine 1, we have achieved the synthesis an A-B-C ring precursor, ent-1-hydroxystemoamide. Key steps involve an ene-yne RCM reaction and a diastereoselective dihydroxylation-lactonization reaction. 
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