Model studies directed toward the boron neutron-capture therapy of cancer: boron delivery to murine tumors with liposomes.

@article{Shelly1992ModelSD,
  title={Model studies directed toward the boron neutron-capture therapy of cancer: boron delivery to murine tumors with liposomes.},
  author={Kenneth Shelly and Debra A. Feakes and M. Frederick Hawthorne and P. G. Schmidt and T A Krisch and William F Bauer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 19},
  pages={9039-43}
}
The successful treatment of cancer by boron neutron-capture therapy (BNCT) requires the selective concentration of boron-10 within malignant tumors. The potential of liposomes to deliver boron-rich compounds to tumors has been assessed by the examination of the biodistribution of boron delivered by liposomes in tumor-bearing mice. Small unilamellar vesicles with mean diameters of 70 nm or less, composed of a pure synthetic phospholipid (distearoyl phosphatidylcholine) and cholesterol, have been… CONTINUE READING