Model studies and first synthesis of the antifungal and antibacterial agent cladobotryal.

@article{Clive2004ModelSA,
  title={Model studies and first synthesis of the antifungal and antibacterial agent cladobotryal.},
  author={D. Clive and X. Huang},
  journal={The Journal of organic chemistry},
  year={2004},
  volume={69 6},
  pages={
          1872-9
        }
}
  • D. Clive, X. Huang
  • Published 2004
  • Chemistry, Medicine
  • The Journal of organic chemistry
The antifungal and antibacterial agent cladobotryal (1) was synthesized by a convergent route from lactone 31 and aldehyde 13, a key step in the elaboration of the pyridinone ring being conversion of a Boc group on nitrogen into a CO(2)SiPr-i(3) group. The simple model compounds 9 and 10, representing the core of cladobotryal and of 5, respectively, were prepared as support studies for making the natural product. 
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