Model of the pathway of –1 frameshifting: Kinetics

@article{Xie2016ModelOT,
  title={Model of the pathway of –1 frameshifting: Kinetics},
  author={Ping Xie},
  journal={Biochemistry and Biophysics Reports},
  year={2016},
  volume={5},
  pages={453 - 467}
}
  • P. Xie
  • Published 10 February 2016
  • Biology, Medicine
  • Biochemistry and Biophysics Reports
Programmed –1 translational frameshifting is a process where the translating ribosome shifts the reading frame, which is directed by at least two stimulatory elements in the mRNA—a slippery sequence and a downstream secondary structure. Despite a lot of theoretical and experimental studies, the detailed pathway and mechanism of the –1 frameshifting remain unclear. Here, in order to understand the pathway and mechanism we consider two models to study the kinetics of the –1 frameshifting… 
Model of the pathway of −1 frameshifting: Long pausing
  • P. Xie
  • Biology, Medicine
    Biochemistry and biophysics reports
  • 2016
TLDR
A model of the pathway of the −1 translational frameshifting during ribosome translation of the dnaX −1 frameshift mRNA is proposed and some predicted results are presented, which can be easily tested by future optical trapping experiments.

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A model of the pathway of the −1 translational frameshifting during ribosome translation of the dnaX −1 frameshift mRNA is proposed and some predicted results are presented, which can be easily tested by future optical trapping experiments.
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