Model of the interactions of calichemicin gamma 1 with a DNA fragment from pBR322.

Abstract

An analysis of the binding interactions of several DNA-drug complexes that utilize carbohydrates for DNA recognition has been undertaken. It is proposed that the carbohydrate residues function as general minor groove binding elements, and the stereochemistry of aglycone attachment sites is generally disposed to promote a right-handed helical geometry that… (More)

Topics

Cite this paper

@article{Hawley1989ModelOT, title={Model of the interactions of calichemicin gamma 1 with a DNA fragment from pBR322.}, author={Ryan Hawley and Laura L Kiessling and Stuart L. Schreiber}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1989}, volume={86 4}, pages={1105-9} }