Model of the L 2 Integrin I-Domain / ICAM-1 DI Interface Suggests That Subtle Changes in Loop Orientation Determine Ligand Specificity

@inproceedings{Legge2002ModelOT,
  title={Model of the L 2 Integrin I-Domain / ICAM-1 DI Interface Suggests That Subtle Changes in Loop Orientation Determine Ligand Specificity},
  author={Glen B. Legge and Garrett M. Morris and Michel F. Sanner and Yoshikazu Takada and Arthur J. Olson and Flavio Grynszpan},
  year={2002}
}
The interaction of the L 2 integrin with its cellular ligand the intercellular adhesion molecule-1 (ICAM-1) is critical for the tight binding interaction between most leukocytes and the vascular endothelium before transendothelial migration to the sites of inflammation. In this article we have modeled the L subunit I-domain in its active form, which was… CONTINUE READING