Model of intracellular calcium cycling in ventricular myocytes.

  title={Model of intracellular calcium cycling in ventricular myocytes.},
  author={Yohannes Shiferaw and Mari A. Watanabe and Alan Garfinkel and James N. Weiss and Alain Karma},
  journal={Biophysical journal},
  volume={85 6},
We present a mathematical model of calcium cycling that takes into account the spatially localized nature of release events that correspond to experimentally observed calcium sparks. This model naturally incorporates graded release by making the rate at which calcium sparks are recruited proportional to the whole cell L-type calcium current, with the total release of calcium from the sarcoplasmic reticulum (SR) being just the sum of local releases. The dynamics of calcium cycling is studied by… CONTINUE READING


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