Model of infantile spasms induced by N-methyl-D-aspartic acid in prenatally impaired brain

@article{Velek2007ModelOI,
  title={Model of infantile spasms induced by N-methyl-D-aspartic acid in prenatally impaired brain},
  author={Libor Vel{\'i}{\vs}ek and Kamran Jehle and Samantha Asche and Jana Vel{\'i}{\vs}kov{\'a}},
  journal={Annals of neurology},
  year={2007},
  volume={61 2},
  pages={109-19}
}
OBJECTIVE Infantile spasms (a catastrophic epileptic syndrome of childhood) are insensitive to classic antiepileptic drugs. New therapies are limited by lack of animal models. Here we develop a new model of flexion spasms based on prenatal exposure to betamethasone combined with postnatal administration of N-methyl-D-aspartic acid (NMDA) and determine brain structures involved in the induction of flexion spasms. METHODS Pregnant rats received two doses of betamethasone on day 15 of gestation… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Neonatal and Infantile Epilepsy: Acquired and Genetic Models.

Cold Spring Harbor perspectives in medicine • 2015
View 11 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…