Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design

@article{Karki2004ModelOF,
  title={Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design},
  author={Rajeshri G. Karki and Yun Tang and Terrence R. Burke and Marc C. Nicklaus},
  journal={Journal of computer-aided molecular design},
  year={2004},
  volume={18 12},
  pages={739-60}
}
We report structural models of the full-length integrase enzyme (IN) of the human immunodeficiency virus type 1 (HIV-1) and its complex with viral and human DNA. These were developed by means of molecular modeling techniques using all available experimental evidence, including X-ray crystallographic and NMR structures of portions of the full-length protein. Special emphasis was placed on obtaining a model of the enzyme's active site with the viral DNA apposed to it, based on the hypothesis that… CONTINUE READING