Model of effectively neutral mutations in which selective constraint is incorporated.

@article{Kimura1979ModelOE,
  title={Model of effectively neutral mutations in which selective constraint is incorporated.},
  author={Motoo Kimura},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1979},
  volume={76 7},
  pages={3440-4}
}
  • Motoo Kimura
  • Published 1979 in
    Proceedings of the National Academy of Sciences…
Based on the idea that selective neutrality is the limit when the selective disadvantage becomes indefinitely small, a model of neutral (and nearly neutral) mutations is proposed that assumes that the selection coefficient (s') against the mutant at various sites within a cistron (gene) follows a Gamma distribution; f(s') = alpha(beta)e(-alphas')s'(beta-1)/Gamma(beta), in which alpha = beta/ s' and s' is the mean selection coefficient against the mutants ( s' > 0; 1 [unk] beta > 0). The… CONTINUE READING

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