Model-guided quantitative analysis of microRNA-mediated regulation on competing endogenous RNAs using a synthetic gene circuit.

@article{Yuan2015ModelguidedQA,
  title={Model-guided quantitative analysis of microRNA-mediated regulation on competing endogenous RNAs using a synthetic gene circuit.},
  author={Ye Yuan and Bing Liu and Peng Xie and Michael Q Zhang and Yanda Li and Zhen Xie and Xiaowo Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 10},
  pages={3158-63}
}
Competing endogenous RNAs (ceRNAs) cross-regulate each other at the posttranscriptional level by titrating shared microRNAs (miRNAs). Here, we established a computational model to quantitatively describe a minimum ceRNA network and experimentally validated our model predictions in cultured human cells by using synthetic gene circuits. We demonstrated that… CONTINUE READING

5 Figures & Tables

Topics

Statistics

020402015201620172018
Citations per Year

79 Citations

Semantic Scholar estimates that this publication has 79 citations based on the available data.

See our FAQ for additional information.