Model-guided design of ligand-regulated RNAi for programmable control of gene expression

Abstract

Progress in constructing biological networks will rely on the development of more advanced components that can be predictably modified to yield optimal system performance. We have engineered an RNA-based platform, which we call an shRNA switch, that provides for integrated ligand control of RNA interference (RNAi) by modular coupling of an aptamer… (More)
DOI: 10.1038/msb.2008.62

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