Model for the architecture of caveolae based on a flexible, net-like assembly of Cavin1 and Caveolin discs.

@article{Stoeber2016ModelFT,
  title={Model for the architecture of caveolae based on a flexible, net-like assembly of Cavin1 and Caveolin discs.},
  author={Miriam Stoeber and Pascale Schellenberger and Christopher Siebert and C{\'e}dric Leyrat and Ari Helenius and Kay Gr{\"u}newald},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 50},
  pages={
          E8069-E8078
        }
}
Caveolae are invaginated plasma membrane domains involved in mechanosensing, signaling, endocytosis, and membrane homeostasis. Oligomers of membrane-embedded caveolins and peripherally attached cavins form the caveolar coat whose structure has remained elusive. Here, purified Cavin1 60S complexes were analyzed structurally in solution and after liposome reconstitution by electron cryotomography. Cavin1 adopted a flexible, net-like protein mesh able to form polyhedral lattices on… CONTINUE READING
Tweets
This paper has been referenced on Twitter 2 times. VIEW TWEETS