Model for the Peptide-Free Conformation of Class II MHC Proteins

  title={Model for the Peptide-Free Conformation of Class II MHC Proteins},
  author={Corrie A. Painter and Anthony Cruz and Gustavo E. L{\'o}pez and Lawrence J Stern and Zarixia Zavala-Ruiz},
  journal={PLoS ONE},
  pages={975 - 1028}
BACKGROUND Major histocompatibility complex proteins are believed to undergo significant conformational changes concomitant with peptide binding, but structural characterization of these changes has remained elusive. METHODOLOGY/PRINCIPAL FINDINGS Here we use molecular dynamics simulations and experimental probes of protein conformation to investigate the peptide-free state of class II MHC proteins. Upon computational removal of the bound peptide from HLA-DR1-peptide complex, the alpha50-59… CONTINUE READING
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