Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

@inproceedings{Lahti2012ModelFL,
  title={Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture},
  author={Anna L. Lahti and Ville J. Kujala and Hugh Chapman and Ari-Pekka Koivisto and Mari Pekkanen-Mattila and Erja Kerkel{\"a} and Jari Hyttinen and Kimmo K. Kontula and Heikki Swan and Bruce R. Conklin and Shinya Yamanaka and Olli Silvennoinen and Katriina Aalto-Set{\"a}l{\"a}},
  booktitle={Disease models & mechanisms},
  year={2012}
}
Long QT syndrome (LQTS) is caused by functional alterations in cardiac ion channels and is associated with prolonged cardiac repolarization time and increased risk of ventricular arrhythmias. Inherited type 2 LQTS (LQT2) and drug-induced LQTS both result from altered function of the hERG channel. We investigated whether the electrophysiological characteristics of LQT2 can be recapitulated in vitro using induced pluripotent stem cell (iPSC) technology. Spontaneously beating cardiomyocytes were… CONTINUE READING
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Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

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