Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA.

@article{Kumar2007ModelFT,
  title={Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA.},
  author={Anuradha Mohan Kumar and Gretchen Meinke and Danielle K. Reese and Stephanie Moine and Paul J. Phelan and Am{\'e}lie Fradet-Turcotte and Jacques Archambault and Andrew Bohm and Peter A. Bullock},
  journal={Journal of virology},
  year={2007},
  volume={81 9},
  pages={4808-18}
}
The interaction of simian virus 40 (SV40) T antigen (T-ag) with the viral origin has served as a model for studies of site-specific recognition of a eukaryotic replication origin and the mechanism of DNA unwinding. These studies have revealed that a motif termed the "beta-hairpin" is necessary for assembly of T-ag on the SV40 origin. Herein it is demonstrated that residues at the tip of the "beta-hairpin" are needed to melt the origin-flanking regions and that the T-ag helicase domain… CONTINUE READING