Model for Glucagon Secretion by Pancreatic α-Cells

  title={Model for Glucagon Secretion by Pancreatic α-Cells},
  author={Virginia Gonz{\'a}lez-V{\'e}lez and Genevi{\`e}ve Dupont and Amparo Gil and Alejandro Machado Gonz{\'a}lez and Iv{\'a}n Quesada},
  booktitle={PloS one},
Glucagon hormone is synthesized and released by pancreatic α-cells, one of the islet-cell types. This hormone, along with insulin, maintains blood glucose levels within the physiological range. Glucose stimulates glucagon release at low concentrations (hypoglycemia). However, the mechanisms involved in this secretion are still not completely clear. Here, using experimental calcium time series obtained in mouse pancreatic islets at low and high glucose conditions, we propose a glucagon secretion… CONTINUE READING