Model-driven rebalancing of the intracellular redox state for optimization of a heterologous n-butanol pathway in Escherichia coli.

@article{Lim2013ModeldrivenRO,
  title={Model-driven rebalancing of the intracellular redox state for optimization of a heterologous n-butanol pathway in Escherichia coli.},
  author={Jae Hyung Lim and Sang Woo Seo and Se Yeon Kim and Gyoo Yeol Jung},
  journal={Metabolic engineering},
  year={2013},
  volume={20},
  pages={56-62}
}
The intracellular redox state plays an important role in the cellular physiology that determines the efficiency of chemical and biofuel production by microbial cell factories. However, it is difficult to achieve optimal redox rebalancing of synthetic pathways owing to the sensitive responses of cellular physiology according as the intracellular redox state changes. Here, we demonstrate optimal rebalancing of the intracellular redox state by model-driven control of expression using n-butanol… CONTINUE READING