Model calibration in the continual reassessment method.

  title={Model calibration in the continual reassessment method.},
  author={Shing M Lee and Ying Kuen Cheung},
  journal={Clinical trials},
  volume={6 3},
BACKGROUND The continual reassessment method (CRM) is an adaptive model-based design used to estimate the maximum tolerated dose in dose finding clinical trials. A way to evaluate the sensitivity of a given CRM model including the functional form of the dose-toxicity curve, the prior distribution on the model parameter, and the initial guesses of toxicity probability at each dose is using indifference intervals. While the indifference interval technique provides a succinct summary of model… CONTINUE READING
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