Model-based prediction of sequence alignment quality

  title={Model-based prediction of sequence alignment quality},
  author={Virpi Ahola and Tero Aittokallio and Mauno Vihinen and Esa Uusipaikka},
  volume={24 19},
MOTIVATION Multiple sequence alignment (MSA) is an essential prerequisite for many sequence analysis methods and valuable tool itself for describing relationships between protein sequences. Since the success of the sequence analysis is highly dependent on the reliability of alignments, measures for assessing the quality of alignments are highly requisite. RESULTS We present a statistical model-based alignment quality score. Unlike other quality scores, it does not require several parallel… CONTINUE READING