Model-based gene set analysis for Bioconductor

  title={Model-based gene set analysis for Bioconductor},
  author={Sebastian Bauer and Peter N. Robinson and Julien Gagneur},
  booktitle={Bioinformatics [ISMB/ECCB]},
UNLABELLED Gene Ontology and other forms of gene-category analysis play a major role in the evaluation of high-throughput experiments in molecular biology. Single-category enrichment analysis procedures such as Fisher's exact test tend to flag large numbers of redundant categories as significant, which can complicate interpretation. We have recently developed an approach called model-based gene set analysis (MGSA), that substantially reduces the number of redundant categories returned by the… CONTINUE READING
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